An Bord Pleanala has refused permission for a new vet clinic near Clifden.
The plans were first approved by county planners - but local residents took an appeal to the higher planning authority.
The new clinic and yard would've been located on a site at Ardbear, around 700m south of Clifden.
Permission was granted in April last year by county planners, with a hefty 24 conditions attached.
But local residents took an appeal to An Bord Pleanala on a number of grounds.
They included the design and layout being inappropriate for the location, and potential traffic issues on a local road near a junction with a regional road.
An Bord Pleanala has now ruled the project cannot go ahead - mainly due to wastewaster concerns, as well as potential impact on conservation sites